KORELASI ENZIM LAKTAT DEHIDROGENASE DENGAN DERAJAT INFEKSI DENGUE PADA PASIEN ANAK
DOI:
https://doi.org/10.47701/infokes.v9i2.830Keywords:
Enzim Laktat Dehidrodenase, Derajat infeksi, Dengue.Abstract
Introduction: Dengue infection is an acute febrile illness, caused by the virus species Flaviviridae. Liver damage and an increase in liver enzymes, due to the direct effect of the virus on the liver cells or the body's immune response against the virus.The presence of non-neutralizing antibodies that form the antibody virus complex causes enhancement of DEN virus infection, stimulates activated macrophages, secretes IL-1, IL-6, TNF alpha, and Platelet Activating Factor.This affects the vascular endothelium resulting in plasma leakage. The purpose of this study was to determine the correlation between lactate dehydrogenase levels and the degree of dengue infection.Method: Retrospective of child hemorrhagic infection patients. Data obtained from medical records. Correlations were analyzed with Spearman (p <0.05 = significant). Results: From 36 subjects, 21 men (58.3%), 15 women (41.7) were found. A total of: 16 (44.4%), 15 (41.7%), 3 (8.3%) and 2 (5.6%) subjects respectively were DHF degrees I, II, III, IV with LDH mean grade I (673.0 + 192.9u / l), grade II (782.9 + 188.7 u / L), grade III (909.3 + 428.2 u / l), grade IV (1118.0 + 110.3 u / l).Conclusion: Patients with pediatric dengue infection need to have liver enzymes examined to evaluate liver damage. Further research is recommended with a larger sample size.
Downloads
References
Burtis CA, Ashwood ER. 2006. Clinical Chemistry and Moleculer Diagnostic, Tietz Textbook. Philadelphia: WB Saunders Company. pp
Centeno V, Quijano D, Vega M. 2008. Biochemical alterations as markers of dengue hemorrhagic fever. Am J Trop Med Hyg. 78:370-374.
Gautret P, Simon F, Her vius Askling H, Bouchaud O, Leparc-Goffart I, Ninove L, Parola P, for EuroTravNet. Dengue type 3 virus infections in European travellers returning from the Comoros and Zanzibar, Februar y-April 2010. Euro Sur veill. 2010;15(15):pii=19541
Hardjoeno. 2007. Interpretasi Klinik IgM dan IgG virus dengue. Dalam: Irwadi dkk Simposium Nasional Demam Berdarah Dengue (DBD), Aspek Biologi Molekuler, Patogenesis, Manajemen, dan Pencegahan Kejadian Luar Biasa. Yogyakarta: Pusat Studi Bioteknologi UGM. pp:1-9
IDAI. 2011. Demam Berdarah Dengue. Dalam: Pudjiadi dkk Pedoman Pelayanan Medis Ikatan Dokter Anak Indonesia. Vol 2.pp: 141-150.
Koliski A, Cat I, Giraldi DJ, Cat ML. 2004. Blood lactate concentration as prognostic marker in critically ill children. J Pediatr. 81(4):287-92.
Kumalawaty J. 2008. Peran Pemeriksaan Antigen dan Antibodi dalam Diagnosis Demam Dengue. Dalam: Setiabudy, R. D., Pendidikan Berkesinambungan Patologi Klinik 2008, Continuing Medical Education & Professional Development, Jakarta: Dept. PK FKUI. pp:230-241.
Samsi TK. 2000. Penatalaksanaan demam berdarah dengue di RS Sumber Waras. Cermin Dunia Kedokteran. 126:5-13.
Santosa D, Alwi EH, Idjradinata PS. 2011. Validitas kadar laktat darah dalam mendeteksi kebocoran plasma pada infeksi virus dengue akut. Maj Kedokt Indon, volum 61, no 2.pp: 23- 25.
Seneviratnea SL, Malavige GN , Silva HJ. 2006. Pathogenesis of liver involvement during dengue viral infections. Transactions of the Royal Society of Tropical Medicine and Hygiene. 100:608-614.
Shu PY, Huang JH. 2004. Current advances in dengue diagnosis. Clin Diag Lab Immunol. 11(4):642-50.
Teichmann D, Gobels K, Niedrig M, Martin P, Grobusch. 2003. Dengue virus infection in travelers returning to Berlin, Germany : Clinical, laboratory, and diagnostic aspects, J Acta Tropica. Vol 90, no 1, pp: 354-357.
Trung et al, 2010. Liver Involvement Associated with Dengue infection in Adults in Vietnam. Am. J. Trop. Med. Hyg., 83(4), 2010, pp. 774–780.
Wildert SA, Schwart E. 2005. Dengue in travelers. N. Eng J. Med. 353:924-32.
World Health Organization. 1997. Dengue Haemorrhagic Fever. Diagnosis, treatment prevention and control. 2nd ed. Geneva: WHO. pp: 12-23.
World Health Organization, 2012. DengueNet. Available. URL: http://www.who.int/mediacentre/factsheets/fs117/en/. Diakses tanggal 19 Januari 2011.
