CERTAINTY FACTORS FOR DETECTING PREECLAMPSIA RISK BASED ON PREGNANCY TRIMESTER: A LITERATURE REVIEW
DOI:
https://doi.org/10.47701/6d5m7c05Keywords:
Certainty Factor, Expert System, Risk Preeclampsia, Knowledge Base, Pregnancy TrimesterAbstract
Preeclampsia is a leading cause of maternal and fetal
death. Early detection of the risk of preeclampsia is
essential. This study aims to analyze the application of the
Certainty Factor method in an expert system for early
detection of preeclampsia risk, identify preeclampsia
symptoms based on trimester of pregnancy, and develop
recommendations for developing a knowledge base that
matches the characteristics of preeclampsia symptoms. The
study used a literature review method through article
searches in the Scopus and Google Scholar databases, a
selection process based on inclusion and exclusion criteria,
extraction, descriptive analysis, and synthesis of eligible
articles. The analysis focused on the application of the
Certainty Factor method, knowledge sources, symptoms
used, inference techniques, diagnostic results, and the
characteristics of preeclampsia symptoms in each trimester
of pregnancy. The results show that the Certainty Factor
method has been widely applied in expert systems to
support early detection of preeclampsia and other
pregnancy-related diseases through rule-based reasoning
and diagnostic confidence level calculations. Research still
uses a static knowledge base without considering changes
in symptom characteristics according to gestational age. It
is proposed that the development of a knowledge base
structured by trimester of pregnancy aims to improve
inference accuracy and reduce misinterpretation of
symptoms.
References
Akbar, M. I. A., Gumilar, K. E., Aziz, M. A., Pribadi, A., Bachnas, M. A., Aryanda, R. A.,
& Dekker, G. (2025). Maternal death associated with preeclampsia in Indonesia.
Pregnancy Hypertension, 42(November), 101400.
https://doi.org/10.1016/j.preghy.2025.101400
Allaam, F., Prasetio, B. H., & Maulana, R. (2023). Sistem Deteksi Dini Penyakit
Preeklampsia Melalui Perubahan Warna Urine Berdasarkan Protein dengan Menggunakan Metode Naive Bayes Classifier. Jurnal Teknologi Informasi dan Ilmu
Komputer, 10(4), 807–814. https://doi.org/10.25126/jtiik.20241046908
Damayani, I., Sudarmin, S., & Piliang, R. (2025). Analisis Hemoroid Pada Ibu Hamil
Dengan Sistem Certainty Factor. Jurnal Sistem Informasi dan Informatika (Simika),
8(2), 236–247. https://ejournal.lppm-unbaja.ac.id/index.php/jsii/article/view/3973
Diningrat, R. S. A., & Marbun, M. (2022). PENERAPAN SISTEM PAKAR DIAGNOSA
SECTIO CAESAREA PADA IBU HAMIL BERBASIS ANDROID DENGAN
MENGGUNAKAN METODE CERTAINTY FACTOR. Jurnal Sistem Informasi
Kaputama (JSIK), 6(1), 7–14.
https://jurnal.kaputama.ac.id/index.php/JSIK/article/view/174
Fitrilina, Albbi, M., Agustian, I., Herawati, A., & Massardi, N. A. (2021). Sistem
Peringatan Awal Resiko Preeklampsia Pada Kehamilan Menggunakan Metoda
Certainty Factor. Jurnal Nasional Teknik Elektro, 10(1), 45–54.
https://doi.org/10.25077/jnte.v10n1.896.2021
Gayatri, M., Indriani, A., Akingbade, O., Mulyadi, J., Fathiyah, N., Pirade, R. A., Indrawan,
I. W. A., Wardani, D. S., & Sutrisno, S. (2022). Verbal Autopsy of Preeclampsia-
related Maternal Death in Jember District, Indonesia: A Case Control Study. Bahrain
Medical Bulletin, 44(4), 1172–1176.
https://www.bahrainmedicalbulletin.com/DECEMBER_2022/BMB-22-295.pdf
Ginting, E. F. (2025). Implementasi Certainty Factor Dalam Mendiagnosa Penyakit Hamil
Anggur (Mola hidatidosa). Jurnal SAINTIKOM (Jurnal Sains Manajemen
Informatika dan Komputer), 24(2), 181–192.
https://doi.org/10.53513/jis.v24i2.12200
Gunung, T. M. R., Ningtyas, A. D., Meidita, D. D., Siregar, M. P., & Rolando, V. (2026).
Sistem Pakar Diagnostik Dini Risiko Preeklampsia pada Ibu Hamil Berbasis
Certainty Factor. Jurnal Rekayasa Teknologi Informasi (JURTI), 10(2), 196–205.
https://e-journals.unmul.ac.id/index.php/INF/article/view/26860
Handito, Z., & Arifin, A. (2023). Sistem Pakar Deteksi Dini Masalah Kesehatan pada Ibu
Hamil Berbasis Web: Literature Review. Automata, 4(1), 1–4.
https://journal.uii.ac.id/AUTOMATA/article/view/26234
Hanif, K. H., Muntiari, N. R., & Ramadhani, P. A. (2022). Penerapan Metode Certainty
Factor untuk Mendiagnosa Penyakit Preekslamsia pada Ibu Hamil dengan
Menggunakan Bahasa Pemrograman Python. Insect (Informatics and Security):
Jurnal Teknik Informatika, 7(2), 63–71. https://doi.org/10.33506/insect.v7i2.1818
Hariyanti, N. S., Nurlaili, A. L., & Aditiawan, F. P. (2026). Expert System Implementation
Using Certainty Factor Method for Early Pregnancy Disease Detection. Journal bit-
Tech, 8(3), 1–11. https://doi.org/10.32877/bt.v8i3.3366
Huppertz, B. (2026). Preeclampsia 2.0: The urgent need for new thinking. Journal of
Reproductive Immunology, 173(August 2025), 104820.
https://doi.org/10.1016/j.jri.2025.104820
Khan, S., Siddique, A. B., Jabeen, S., Hossain, A. T., Haider, M. M., Zohora, F. T.,
Rahman, M. M., El Arifeen, S., Rahman, A. E., & Jamil, K. (2023). Preeclampsia
and eclampsia-specific maternal mortality in Bangladesh: Levels, trends, timing, and
care-seeking practices. Journal of Global Health, 13, 1–12.
https://doi.org/10.7189/JOGH.13.07003
Latifah, N., Haryono, I., & Yuliana, F. (2023). Midwifery Care for Pregnant Women in
Trimester III with Pre-eclampsia at RSUD Dr H. Moch. Ansari Saleh Banjarmasin.
International Student Conference of Global Multidisciplinary Collaboration
(INTEGRATION), 1(1), 114–119.
https://ocs.unism.ac.id/index.php/integration/article/view/1001
Lyu, G., Liao, R., Jiang, Q., He, X., & Weng, Z. (2025). Chinese Expert Consensus on
ultrasound anatomical examination of fetuses at 11 + 0 to 13 + 6 weeks of gestation
based on the Delphi method. Archives of Gynecology and Obstetrics, 312(6), 1937–
1954. https://doi.org/10.1007/s00404-025-08231-z
Manek, S. S., Mada, G. S., & Kelen, Y. P. K. (2023). Pre-Eclampsia Diagnosis Expert
System Using Fuzzy Inference System Mamdani. Jurnal Techno Nusa Mandiri,
20(2), 80–88. https://doi.org/10.33480/techno.v20i2.4622
Mola, S. A. S., Tokan, D. I. C., & Widiastuti, T. (2023). Sistim Pakar Diagnosis Gangguan
Pada Kehamilan Trimester Pertama Menggunakan Metode Certainty Factor Berbasis
Web. Jurnal Dialektika Informatika (Detika), 4(1), 13–18.
https://doi.org/10.24176/detika.v4i1.11427
Nujoom, R. R., Babader, R. B., Aloufi, A. A., Malibary, M., Alshareef, N. H., Shoaib, F.
M., Almteri, A., Al Maqwashi, L. S., & Alrafi, M. D. (2025). Preeclampsia in Saudi
Arabia: A Systematic Review and Meta-Analysis of Prevalence, Risk Factors,
Awareness, and Outcomes. Cureus, 17(12), 1–18.
https://doi.org/10.7759/cureus.98969
Nureza, M. B., & Arifin, A. (2023). Penerapan Sistem Pakar untuk Mendeteksi Dini
Masalah Kesehatan Ibu Hamil: Systematic Literature Review. Jurnal Minfo Polgan,
12(1), 797–803. https://doi.org/10.33395/jmp.v12i1.12497
Nurhayati, N., Farida, S., & Palupi, D. L. M. (2022). Sistem Cerdas Kesehatan Ibu Hamil
Menggunakan Metode Certainty Factor. Prosiding Seminar Nasional Teknologi
Informasi dan Bisnis (SENATIB) 2022, 228–235.
https://ojs.udb.ac.id/index.php/Senatib/article/view/1891/1481
Oumbarek, K., Lkoul, A., Mahlaq, S., El Hilali, S., Sbai Idrissi, K., & Obtel, M. (2025).
Factors associated with maternal death from severe preeclampsia in the post-
pandemic era: a cross-sectional study from Southern Morocco. BMC Pregnancy and
Childbirth, 25(1), 1–9. https://doi.org/10.1186/s12884-025-08139-1
Prasetya, N. W. A., Wanti, L. P., Sari, L., & Puspitasari, L. (2022). Sistem Pakar Deteksi
Dini Penyakit Preeklamsia pada Ibu Hamil Menggunakan Metode Certainty Factor.
Infotekmesin, 13(1), 168–177. https://doi.org/10.35970/infotekmesin.v13i1.1050
Pribadi, A. (2021). Zero mother mortality preeclampsia program: Opportunity for a rapid
acceleration in the decline of maternal mortality rate in Indonesia. International
Journal of Women’s Health and Reproduction Sciences, 9(3), 160–163.
https://doi.org/10.15296/ijwhr.2021.30
Puspita, S., Yanto, G., Turaina, R., & Putri, N. E. (2026). Early Prediction of Preeclampsia
Using Ensemble Machine. Telehealth and Medicine Today, 11(1), 1–13.
https://telehealthandmedicinetoday.com/index.php/journal/article/view/663
Rahman, R. T. A., Lakulu, M. M., & Panessai, I. Y. (2023). Advancing Preeclampsia
Prediction with Machine Learning: A Comprehensive Systematic Literature Review.
International Journal of Intelligent Systems and Applications in Engineering, 11(3),
13–23. https://ijisae.org/index.php/IJISAE/article/view/3138
Ramadhan, R., Jamaludin, A., & Solehudin, A. (2023). Sistem Pakar Diagnosis Penyakit
Berdasarkan Keluhan Saat Kehamilan Menggunakan Metode Forward Chaining Dan
Certainty Factor (Studi Kasus : Klinik Alqila). INFOTECH journal, 9(2), 418–430.
https://doi.org/10.31949/infotech.v9i2.6320
Santi, D. R., Suminar, D. R., Devy, S. R., & Mahmudah. (2023). Pregnant women
behaviours in early detection of preeclampsia warning signs based on health belief
model: A structural equal modelling analysis. Pharmacy Education, 23(4), 76–81.
https://doi.org/10.46542/pe.2023.234.7681
Sebastian, S. A., Singh, K., & Padda, I. (2023). Isolated sixth nerve palsy as the first manifestation of preeclampsia. Radiology Case Reports, 18(4), 1411–1414.
https://doi.org/10.1016/j.radcr.2023.01.012
Sundari, S. S., Sarmidi, S., & Nuraropah, A. F. (2021). Sistem Pakar Diagnosis Penyakit
Gangguan Kehamilan Menggunakan Metode Forward Chaining Dan Certainty
Factor Berbasis Web. It (Informatic Technique) Journal, 9(2), 164.
https://doi.org/10.22303/it.9.2.2021.164-175
Tahir, A., Hendriyanto, D., Faizah, A., Anshory, J., & Harun, R. (2024). Application of
Forward Chaining and Rule-Based Reasoning Methods to Design an Expert System
for Pregnant Women Disease Diagnosis in a Private Hospital. Jurnal Informasi dan
Teknologi, 6, 93–98. https://doi.org/10.60083/jidt.v6i1.480
Tamas, P., Farkas, B., & Betlehem, J. (2025). Practical Considerations Concerning
Preeclampsia Subgroups. Journal of Clinical Medicine, 14(7), 1–13.
https://doi.org/10.3390/jcm14072498
Tarigan, E. B. (2021). Expert System for Diagnosis of Pests and Diseases of Citrus Plants
using the Certainty Factor Method (Case Study in Deram Village, Karo Regency).
International Journal of Basic and Applied Science, 10(1), 9–15.
https://doi.org/https://doi.org/10.35335/ijobas.v10i1.1
Tarigan, K. D. A., Simanjuntak, M., & Maulita, Y. (2024). Expert System of Preeclampsia
Diagnosis Using Certainty Factor Method. Journal of Mathematics and Technology
(MATECH), 3(2), 169–179. https://doi.org/10.63893/matech.v3i2.176
Vadlisky, F. D., Hamdani, H., & Agus, F. (2025). Expert System for Early Detection of
High-Risk Pregnancy Conditions Using Certainty Factor and Forward Chaining
Methods. JCSE Journal of Computer Science an Engineering, 6(1), 1.
https://icsejournal.com/index.php/JCSE/article/view/826
Wati, E. F., Sunita Perangin-Angin, E., & Sudrajat, B. (2023). Pregnancy Disease
Diagnostic Expert System With Certainty Factor Method. International Journal of
Information System & Technology, 6(158), 754–760.
https://ijistech.org/ijistech/index.php/ijistech/article/view/292
WHO. (2011). WHO recommendations for Prevention and treatment of pre-eclampsia and
eclampsia. In WHO (Vol. 97). WHO.