SYSTEMATIC REVIEW : EFEK ANTIOKSIDAN DAN ANTIINFLAMASI DARI SPESIES TUMBUHAN SURUHAN (PEPEROMIA PELLUCIDA L.)
DOI:
https://doi.org/10.47701/sikenas.vi.2865Keywords:
peperomia pellucida, antioxsidant, oxidan, oxidatif, antiinflammation, antiimflamatoryAbstract
Sel manusia memiliki potensi antioksidan yang rendah dan menghasilkan lebih banyak spesies oksigen reaktif. Spesies reaktif yang berlebihan dapat menyebabkan stres oksidatif lokal dan cedera jaringan, sehingga menimbulkan beberapa penyakit. Suruhan (Peperomia pellucida L) merupakan tanaman herba yang memiliki kegunaan etnomedisin. Tinjauan literatur ini dilakukan untuk menilai data yang diterbitkan menyelidiki aktivitas antioksidan dan anti-inflamasi Peperomia pellucida L untuk mendukung desain penelitian masa depan. Tinjauan ini dilakukan dengan pedoman Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). Informasi diperoleh melalui database elektronik PubMed, Google Scholar, dan Science Direct sejak 2017 hingga Maret 2022. Kandungan fitokimia Peperomia pellucida antara lain alkaloid, flavonoid, sterol, tanin, gula pereduksi, asam amino, saponin, triterpenoid yang memiliki aktivitas antioksidan. dalam menghambat pembentukan radikal bebas. Dan pengujian efek anti inflamasi menggunakan metode ANTI-LOX (anti-Lipoxygenase enzyme). Radikal bebas yang berlebihan dapat menyebabkan kerusakan makromolekul seperti protein (enzim), lipid dan DNA yang mengarah pada kondisi stres oksidatif sehingga menimbulkan patogenesis berbagai penyakit, termasuk peradangan. Hasil tinjauan sistematis ini menunjukkan adanya aktivitas antioksidan dan aktivitas antiinflamasi, sehingga memberikan perspektif untuk penelitian selanjutnya. Peperomia pellucida L sebagai sumber suplemen antioksidan dan anti-inflamasi yang potensial.
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