Teratogenic Tinospora Cordifolia And Carica Papaya On White Mouse Fetuses (Mus Musculus)
DOI:
https://doi.org/10.47701/icohetech.v5i1.4241Keywords:
Traditional Medicine, Tinospora Cordifolia And Carica Papaya, Teratogenic TestAbstract
Tinospora cordifolia and Carica papaya in the production of traditional herbal medicines, specifically in formulations known as tinospora cordifolia and Carica papaya herbal mixtures. Extracts from Tinospora cordifolia stems and Carica papaya contain bioactive flavonoid antioxidants, which can inhibit phosphodiesterase enzymes that hydrolyze cAMP. Elevated cAMP concentrations can impede growth acceleration. This research aims to assess the teratogenic effects on the fetuses of white mice after administering tinospora cordifolia and carica papaya extracts. The study involved 25 Mus musculus divided into five groups. The first group, serving as the negative control, received 0.5% Na CMC, while the second group, serving as the positive control, was injected with intravenous Cyclophosphamide at 50 mg/kg. The other groups were administered various doses: ET Dose 1120, ECP Dose 1120, Dose 1 ETCP 2:1, Dose 2 ETCP 1:2, and Dose 3 ETCP 1:1. The extracts were given during the organogenesis period, and on the 18th day, the mice underwent laparotomy to collect the fetuses. The research findings indicate that tinospora cordifolia and carica papaya extracts can cause teratogenic effects, particularly at Dose 3 ETCP 1:1.
References
Alafiatayo, A. A., Lai, K. S., Syahida, A., Mahmood, M., & Shaharuddin, N. A. (2019). Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio). Evidence-Based Complementary and Alternative Medicine, 2019. https://doi.org/10.1155/2019/3807207
Amalia Choironi, N. (2016). QUALITY STANDARDIZATION OF BROTOWALI (Tinospora crispa) STEM EXTRACT STANDARDISASI KUALITAS EKSTRAK BATANG BROTOWALI (Tinospora crispa). Traditional Medicine Journal, 21(1), 2016.
Bagas Ardiyantoro. (2024a). TERATOGENIC TEST OF BROTOWALI STEM EXTRACT (Tinospora crispa) AND TEMULAWAK RHIZOME EXTRACT (Curcuma xanthorrhiza) ON WHITE MOUSE FETUSES (Mus musculus). Journal Eduvest - Journal of Universal Studies, 4(1). https://doi.org/https://doi.org/10.59188/eduvest.v4i1.999
Bagas Ardiyantoro, A. M. P. M. (2024b). Teratogenic Test Of Brotowali Stem Extract (Tinospora Crispa) And Temulawak Rhizome Extract (Curcuma Xanthorrhiza) On White Mouse Foetuses (Mus Musculus). https://doi.org/https://doi.org/10.59188/eduvest.v4i1.999
Basu, P., Meza, E., Bergel, M., & Maier, C. (2020). Estrogenic, antiestrogenic and antiproliferative activities of euphorbia bicolor (Euphorbiaceae) latex extracts and its phytochemicals. Nutrients, 12(1). https://doi.org/10.3390/nu12010059
Elba, F., Hilmanto, D., & Poddar, S. (2022). Factors influencing the use of herbal medications during pregnancy at Public Health Center, Indonesia. Journal of Public Health Research, 11(4). https://doi.org/10.1177/22799036221139939
Fatikhurokhmah, H. M., Agustini, R., Kimia, J., Matematika, F., Ilmu, D., & Alam, P. (2022). Concentration Effect of Brotowali Stem (Tinospora Crispa (L.)) in Ethanol Extracts on the ?-Glukosidase Enzyme Inhibition. In Indonesian Journal of Chemical Science (Vol. 11, Issue 3). http://journal.unnes.ac.id/sju/index.php/ijcs
Illamola, S. M., Amaeze, O. U., Krepkova, L. V., Birnbaum, A. K., Karanam, A., Job, K. M., Bortnikova, V. V., Sherwin, C. M. T., & Enioutina, E. Y. (2019). Use of herbal medicine by pregnant women: What physicians need to know. Frontiers in Pharmacology, 10. https://doi.org/10.3389/fphar.2019.01483
Ismail, H. F., Hashim, Z., Soon, W. T., Rahman, N. S. A., Zainudin, A. N., & Majid, F. A. A. (2017). Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo. Journal of Traditional and Complementary Medicine, 7(4), 452–465. https://doi.org/10.1016/j.jtcme.2016.12.006
Kong, Y. R., Jong, Y. X., Balakrishnan, M., Bok, Z. K., Weng, J. K. K., Tay, K. C., Goh, B. H., Ong, Y. S., Chan, K. G., Lee, L. H., & Khaw, K. Y. (2021). Beneficial role of carica papaya extracts and phytochemicals on oxidative stress and related diseases: A mini review. In Biology (Vol. 10, Issue 4). MDPI AG. https://doi.org/10.3390/biology10040287
Mohamad, T. A. S. T., Islahudin, F., Jasamai, M., & Jamal, J. A. (2019). Preference, perception and predictors of herbal medicine use among malay women in Malaysia. Patient Preference and Adherence, 13, 1829–1837. https://doi.org/10.2147/PPA.S227780
Santana, L. F., Inada, A. C., Santo, B. L. S. do E., Filiú, W. F. O., Pott, A., Alves, F. M., Guimarães, R. de C. A., Freitas, K. de C., & Hiane, P. A. (2019). Nutraceutical potential of carica papaya in metabolic syndrome. In Nutrients (Vol. 11, Issue 7). MDPI AG. https://doi.org/10.3390/nu11071608
Supriatin, Y., Sari, N., Syafrullah, H., Jurusan, ), Konsentrasi, K., Medis, A., Tinggi, S., Bakti, A., Bandung, A., Stikes, ), Husada, D., Kunci, K., & Brotowali, B. (2018). PEMANFAATAN EKSTRAK BATANG BROTOWALI (Tinospora Crispa) MENGGUNAKAN PELARUT METHANOL SEBAGAI LARVASIDA NYAMUK Aedes aegypti.
Vargesson, N. (2019). The teratogenic effects of thalidomide on limbs. Journal of Hand Surgery: European Volume, 44(1), 88–95. https://doi.org/10.1177/1753193418805249
Yuandani, Tarigan, K. S. A., & Yuliasmi, S. (2021a). Teratogenic effects of ethanol extract of Curcuma mangga Val. rhizomes in wistar rats. Toxicological Research, 37(4), 429–434. https://doi.org/10.1007/s43188-020-00074-x
Yuandani, Tarigan, K. S. A., & Yuliasmi, S. (2021b). Teratogenic effects of ethanol extract of Curcuma mangga Val. rhizomes in wistar rats. Toxicological Research, 37(4), 429–434. https://doi.org/10.1007/s43188-020-00074-x
Yuandani, Tarigan, K. S. A., & Yuliasmi, S. (2021c). Teratogenic effects of ethanol extract of Curcuma mangga Val. rhizomes in wistar rats. Toxicological Research, 37(4), 429–434. https://doi.org/10.1007/s43188-020-00074-x
