CORRELATION BETWEEN RPR AND O AGGLUTININ TITERS IN TYPHOID FEVER

Abstract

Typhoid fever remains a significant disease burden in developing countries like Indonesia. The Widal O test is commonly used for supportive diagnosis, but cross-reactivity and background antibodies limit its interpretation in endemic regions. Recently, the Red Cell Distribution Width-to-Platelet Ratio (RPR) has emerged as a novel inflammatory marker. This retrospective analytical study evaluated the correlation between RPR and Widal O titers in 32 adult patients with suspected typhoid fever. Data including RDW, platelet count, and Widal O titers were collected from medical records. RPR was calculated as RDW (%) divided by platelet count (10³/?L). Spearman's rank correlation test showed a mean RPR value of 0.063 ± 0.027, with Widal O titers ranging from 1:80 to 1:320. A weak but statistically significant positive correlation was found between RPR and Widal O titers (r = 0.391, p = 0.027). In conclusion, RPR correlates positively with Widal O titers, suggesting its potential as a cost-effective supportive inflammatory marker alongside traditional serological testing in typhoid fever patients.